Anemia is assocated with both very low and very high vitamin D (Mexican seniors) – Oct 2021

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Etiology of Anemia in Older Mexican Adults: The Role of Hepcidin, Vitamin A and Vitamin D

Nutrients. 2021 Oct 27;13(11):3814. doi: 10.3390/nu13113814.
Vanessa De la Cruz-Góngora 1, Aarón Salinas-Rodríguez 1, Mario Flores-Aldana 2, Salvador Villalpando 2

Anemia in older adults is a growing public health issue in Mexico; however, its etiology remains largely unknown. Vitamin A deficiency (VAD) and vitamin D deficiency (VDD) have been implicated in the development of anemia, though by different mechanisms. The aim of this study is to analyze the etiology of anemia and anemia-related factors in older Mexican adults. This is a cross-sectional study of 803 older adults from the southern region of Mexico in 2015. The anemia etiologies analyzed were chronic kidney disease (CKD), nutritional deficiencies (ND), anemia of inflammation (AI), anemia of multiple causes (AMC) and unexplained anemia (UEA). VAD was considered to be s-retinol ≤ 20 μg/dL, and VDD if 25(OH)D < 50 nmol/L. IL-6 and hepcidin were also measured. Multinomial regression models were generated and adjusted for confounders. Anemia was present in 35.7% of OA, independent of sex. UEA, CKD, AI and ND were confirmed in 45%, 29.3%, 14.6% and 7% of older adults with anemia, respectively. Hepcidin and log IL-6 were associated with AI (p < 0.05) and CKD (p < 0.001). VAD was associated with AI (p < 0.001), and VDD with ND and AMC (p < 0.05). Log-IL6 was associated with UEA (p < 0.001). In conclusion, anemia in older adults has an inflammatory component. VAD was associated to AI and VDD with ND and AMC.
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VitaminDWiki - Overview Iron Supplements and Vitamin D has the following table by Mercola

Diseases associated with

Low iron (menstruating)	High iron (males)
Anemia	Anemia of chronic disease
Fibromyalgia	Premature aging
Inflammatory bowel disease	Atherosclerosis
Hypothyroidism	Anorexia
Depression / anxiety	Grave's disease
Attention deficit hyperactivity disorder	Heart arrhythmia
Parkinson's disease	Cancer
Neurodegenerative conditions	Sideroblastic anemia
Celiac disease	Nonalcoholic fatty liver disease (NAFLD). Excess dietary fructose is a primary initiator of NAFLD, but high iron is another culprit that triggers disease progression
Restless leg syndrome	Liver damage and liver disease
Hair loss	Still's disease
Muscle weakness, decline in motor skills	Hemochromatosis
Mental changes and memory loss	Hemophagocytic syndrome

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Vitamin D pages containing "anemia" in title (15 as of Sept 2021)

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See also VitaminDWiki

• Iron deficiency is a cause of Vitamin D deficiency also reviews other forms of Iron
• Anemia 1.9X more likely in white children having lowish vitamin D – Jan 2014
• Iron and Vitamin D deficiencies are synergistic - April 2015
• Anemia in pregnant teens 7X more likely if low vitamin D – April 2015
• All items in category Iron and Vitamin D 68 items
• Vitamin D levels over 150 nanograms associated with somewhat lower haemoglobin, etc (details behind paywall) – Nov 2021